@ University of Tennessee Health Science Center

CTC-RG-2021 Program

CTC-RG 18th Annual Meeting. Models for precision medicine. September 1-3, 2021.

The 18th Annual Meeting of the Complex Trait Community in collaboration with the Rat Genomics Community was hosted by Hager Reinmar at the University of Manchester, UK and run virtually on September 1-3, 2021.

Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Welcome and Introduction Hager Reinmar University of Manchester, UK
3:15 pm 9:15 am Genetics, Omics, and Live FAIR+ Data Reanalysis using Workbooks and GeneNetwork Williams Robert University of Tennessee Health Science Center, USA
3:30 pm9:30 amGenetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cellsBaker ChristopherThe Jackson Laboratory, USA
3:45 pm9:45 amNIDA center for genetic studies of drug abuse in outbred ratsPalmer AbrahamUniversity of California San Diego, USA
4:00 pm10:00 amIdentification of regulatory landscape in multiple brain regions of outbred heterogeneous stock ratsMunro DanielUniversity of California San Diego, USA
4:15 pm10:15 amBREAK
4:30 pm10:30 amDiscovery of Heritable Cancer Risk Genes Using Diversity Outbred F1 mice That Express HER2/Neu OncogeneWei Wei-ZenWayne State University, USA
4:45 pm10:45 amNatural genetic variation alters Alzheimer's-related gene expression modules in miceWells AnnThe Jackson Laboratory, USA
5:00 pm11:00 amA BALB/c reduced complexity cross identifies Zhx2 as a candidate underlying oxycodone metabolite brain concentration and state-dependent learningBeierle JacobBoston University, USA
5:15 pm11:15 amGenetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity crossBryant CamronBoston University, USA
5:30 pm11:30 amBREAK
5:45 pm11:45 amRegulation of protein abundance in genetically diverse mouse populationsKeele GregThe Jackson Laboratory, USA
6:00 pm12:00 pmGenetic dissection of the pluripotent proteomeAydin SelcanThe Jackson Laboratory, USA
6:15 pm12:15 pmPower and precision: Evaluation and recommendations of quantitative trait analysis methods for RNA expression levels in the Hybrid Rat Diversity PanelPattee JackUniversity of Colorado, USA
6:30 pm12:30 pmTranscriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Novel Genetic Regulatory Mechanisms Relevant for Obesity in HumansSolberg Woods LeahWake Forest University, USA
6:45 pm12:45 pmBREAK
7:00 pm1:00 pmBREAK
7:15 pm1:15 pmInvestigating the gut-brain axis in 4,006 P50 Heterogeneous Stock ratsBaud AmelieCentre for Genomic Regulation, Spain
7:30 pm1:30 pmDifferential Mechanisms Dictate Cholesterol Levels in Chow-fed Versus High fat diet-fed MiceCousineau CodyUniversity of Michigan, USA
7:45 pm1:45 pmBREAK
8:00 pm2:00 pmCANCELLED Connecting DCX, COMT and FMR1 in Social Behavior and Cognitive Impairment Manoj DevikaDelprato lab, USA 
8:00 pm2:00 pmA general hidden Markov model for multi-parent populationsBroman KarlUniversity of Wisconsin - Madison
8:15 pm2:15 pmSodium accumulation and blood capillary rarefaction in the skin predisposes spontaneously hypertensive rats to salt sensitive hypertensionPravenec Michal Czech Academy of Sciences, Czech Republic
8:15 pm2:15 pmIntegrated transcriptomic analysis reveals unique NASH progression in Leptin deficient ratsZhu XianminShanghai Tech University, China
8:30 pm2:30 pmIdentification of novel QTL linked to the metabolic syndrome in the Berlin Fat MouseDelpero Manuel Humboldt University Berlin, Germany
8:30 pm2:30 pmProjecting human and rat GWAS into network space identifies shared genetic control of BMI and heightLeger BrittanyUniversity of California San Diego, USA
8:45 pm2:45 pmHigh-fat diet generally exacerbates, but is sometimes protective against, cognitive dysfunction in female AD mice depending on genetic backgroundDunn AmyThe Jackson Laboratory, USA
9:00 pm3:00 pmEnd of Day 1
Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Congenic Mapping and Comparative Genomics of Rat Mammary Carcinoma Susceptibility Locus, Mcs3 Duderstadt Emily University of Louisville, USA
3:15 pm 9:15 am Integrating the Collaborative Cross genetic reference panel with Chd8 haploinsufficiency to discover mechanisms regulating behavioral heterogeneity. Tabbaa Manal University of Southern California, USA
3:30 pm9:30 amGenetic Analysis of the "Levin Rat" - a Rodent Model of Diet-Sensitive ObesityGoffer YossefColumbia University, USA
3:45 pm9:45 amPolymorphic SNPs, short tandem repeats and structural variants cause differential gene expression among inbred C57BL/6 and C57BL/10 substrainsMortazavi MiladUniversity of California San Diego, USA
4:00 pm10:00 amBREAK
4:15 pm10:15 amHuman-GWAS and rat Mcs1b nominated MIER3 is a causal breast cancer susceptibility geneSamuelson DavidUniversity of Louisville, USA
4:30 pm10:30 amGenetic analysis of multiple measures of locomotor activity in 2,325 outbred Heterogeneous Stock ratsChitre ApurvaUniversity of California San Diego, USA
4:45 pm10:45 amKeratinocyte-associated protein 3 impacts eating behavior and adiposity differentially based on environmental influencesSzalanczy AlexandriaWake Forest University, USA
5:00 pm11:00 amGenetically diverse mouse embryonic stem cells enable inference of genetic regulatory structureKuffler LaurenThe Jackson Laboratory, USA
5:15 pm11:15 amBREAK
5:30 pm11:30 amGenetic mapping of multiple metabolic traits identifies novel genes for adiposity and insulin secretory capacity in outbred ratsLe Thu HongUniversity College London, UK
5:45 pm11:45 amA wild-derived mutator locus drives germline mutation spectrum differences in a genetically diverse murine familyHarris KelleyUniversity of Washington, USA
6:00 pm12:00 pmAutomated high-throughput analysis of gait and whole body posture in JAX-KOMP2 pipeline identifies regulators of motor functionsSabnis GautamThe Jackson Laboratory, USA
6:15 pm12:15 pmBREAK
6:30 pm12:30 pmBREAK
6:45 pm12:45 pmGenetic basis for unilateral renal agenesis in heterogenous stock ratsLeal-Gutierrez Joel DavidUniversity of California San Diego, USA
7:00 pm1:00 pmGenome-wide association study (GWAS) of complex behavioral traits in larval zebrafish Xu JialeUniversity of California San Francisco, USA
7:00 pm1:00 pmHigh-throughput genotyping of zebrafish enables GWAS in outbred EKW populationPolesskaya OksanaUniversity of California San Diego, USA
7:15 pm1:15 pmBREAK
7:30 pm1:30 pmRat Genome Database (RGD): A multi-species resource to explore complex diseaseSmith JenniferMedical College of Wisconsin, USA
7:45 pm1:45 pmRGD - Multi-Ontology Enrichment Tool (MOET) - A Bioinformatics Tool for Ontology Analysis Across Multiple Species and Ontologies Vedi  Mahima Medical College of Wisconsin, USA 
7:45 pm1:45 pmRGD - Rat strain updates at the Rat Genome Database (RGD)Wang Shur-JenMedical College of Wisconsin, USA
8:00 pm2:00 pmRGD - Quantitative Data Curation for the Hybrid Rat Diversity Panel (HRDP) in RGD’s PhenoMiner Database Kwitek  AnneMedical College of Wisconsin, USA 
8:00 pm2:00 pmRGD - Comparison of genomic variants discovery in HRDP inbred rat strains with two rat genome referencesTutaj MonikaMedical College of Wisconsin, USA
8:15 pm2:15 pmRGD - Rat Reference mRatBN7.2 Update and CurationDemos WendyMedical College of Wisconsin, USA
8:30 pm2:30 pmRGD DiscussionKwitek AnneMedical College of Wisconsin, USA
9:00 pm3:00 pmEnd of Day 2
Time (BST) Time (CDT) Title Speaker Affiliation
3:00 pm 9:00 am Bayesian modeling of skewed X inactivation in genetically diverse mice reveals a novel Xce allele and hidden properties of embryonic composition Valdar William University of North Carolina Chapel Hill, USA
3:15 pm 9:15 am Genetics and sex, but not gene by diet interactions, contribute to metabolic and behavioral responses to high fat diet in heterogeneous stock rats Deal Aaron Wake Forest University, USA
3:30 pm9:30 amOpen field nocifensive behavior assayHession LeinaniThe Jackson Laboratory, USA
3:45 pm9:45 amGenetic Architecture of Heart Mitochondrial Proteome influencing Cardiac HypertrophyChella Krishnan KarthickeyUniversity of Cincinnati, USA
4:00 pm10:00 amBREAK
4:15 pm10:15 amGenome-wide association study identifies Taar1 as a candidate gene underlying the response to a Pavlovian reward cuesMeyer PaulUniversity at Buffalo, USA
4:30 pm10:30 amLow-Coverage Whole Genome Sequence Genotyping Pipeline for Peromyscus CalifornicusChen DenghuiUniversity of California San Diego, USA
4:45 pm10:45 ammRatBN7 ushers in a new era of rat genomics and genetics researchChen HaoUniversity of Tennessee Health Science Center, USA
5:00 pm11:00 amBREAK
5:15 pm11:15 amBREAK
5:30 pm11:30 amQuantitative trait locus implicates expression of a mismatch repair protein in STR expansion propensity in miceMaksimov MikhailUniversity of California San Diego, USA
5:45 pm11:45 amGenetic Architecture of Transcript Levels in RatsIm Hae KyungUniversity of Chicago, USA
6:00 pm12:00 pmGenetics of Unsupervised Learning Based Mouse Behavior SpaceKumar VivekThe Jackson Laboratory, USA
6:15 pm12:15 pmMulti-omics, more than the sum of its partsVacher CoraIllumina, UK
6:30 pm12:30 pmBREAK
6:45 pm12:45 pmBREAK
7:00 pm1:00 pmIdentifying Protein Complexes Binding to Risk Functional Variants in the Uromodulin PromoterMcBride Martin University of Glasgow, UK
7:00 pm1:00 pmA novel µ-opioid receptor transgenic Cre rat: Cellular and behavioral characterizationSaunders ThomUniversity of Michigan, USA
7:15 pm1:15 pmComparing different quantification methods for delayed reward discountingMitchell Suzanne Oregon Health & Science University, USA
7:15 pm1:15 pmStrain Nomenclature Curation: From Repository to IMSR to MGIPerry MichelleThe Jackson Laboratory, USA
7:30 pm1:30 pmThe Bayesian Network Webserver: A tool for network modeling of system genetics dataZiebarth Jesse University of Tennessee Health Science Center, USA 
7:30 pm1:30 pmInvestigating the effect of a large deletion in intron 8 of the Bbs7 gene on the Berlin Fat Mouse phenotypeKrause FlorianHumboldt University Berlin, Germany
7:45 pm1:45 pmBREAK
8:00 pm2:00 pmDominance genetic effects on complex traits in pigs, rats and mice are associated with trans-acting dominance gene expression effectsCui LeileiUniversity College London, UK 
8:00 pm2:00 pmPreliminary Analysis of Cocaine Sensitivity in a Genome-Wide Association Study Involving Heterogeneous Stock RatsRakowski ElizabethUniversity at Buffalo, USA
8:15 pm2:15 pmGWAS on socially acquired nicotine IVSA in heterogeneous stock rats highlights genes implicated in human smoking behaviorWang Tengfei University of Tennessee Health Science Center, USA 
8:15 pm2:15 pmGenome-wide association study on behaviors in an open field in outbred rats identifies multiple loci implicated in psychiatric disordersGunturkun HakanUniversity of Tennessee Health Science Center, USA
8:30 pm2:30 pmQTL mapping in Collaborative Cross mice reveals candidate loci modulating severe coronavirus diseaseRisemberg EllenUniversity of North Carolina Chapel Hill, USA
8:45 pm2:45 pmPrize announcement and thanksHager ReinmarThe University of Manchester, UK
8:45 pm2:45 pmCTC and Rat Genomics in Colorado 2022Saba LauraUniversity of Colorado, USA
9:00 pm3:00 pmClose of meeting