@ University of Tennessee Health Science Center

CTC-RG-2022 Program

CTC-RG 19th Annual Meeting University of Colorado. September 29th and 30th 2022.

The 19th Annual Meeting of the Complex Trait Community, in collaboration with the Rat Genomics Community, will be held at the University of Colorado Anschutz Medical Campus as a hybrid meeting on September 29 th and 30 th 2022.

The meeting will be held in the Education 2 South Building on campus

Index Type Time (MDT) Title Speaker Affiliation
01 8:00 am Registration open/Light Breakfast
02 9:00 am Plenary Session #1
03 Leveraging public data with machine learning to study complex diseases Arjun Krishnan, PhD University of Colorado Anschutz Medical Campus
0410:00 amDiscussion
0510:30 amBREAK
06Virtual10:45 amSpontaneous nonsense mutation in Tuft1 (tuftelin 1) gene is associated with amelioration of glucose and lipid metabolism in the BXH6 subline of rat recombinant inbred strainsMichal PravenecInstitute of Physiology, Czech Academy of Science
07Virtual11:00 amIdentifying modulators of optic nerve numbers and health in glaucoma using systems geneticsAman KumarUniversity of Tennessee Health Science Center
08Virtual11:15 amA novel pre-clinical model identifies genetic modifiers of triple negative breast cancer risk and progressionDavid AshbrookUniversity of Tennessee Health Science Center
09Virtual11:30 amReplicated loci that modulate lifespan and longevity in females of the BXD family on Chr 1 and Chr 3Suheeta RoyUniversity of Tennessee Health Science Center
1011:45 amLunch - box lunches provided
11In-person12:45 pmDistinct genetic mechanism associated with phenotype response in chow-fed versus high fat diet-fed miceCody CousineauUniversity of Michigan School of Public Health
12In-person1:00 pmCocaine addiction is associated with long-term changes in gene regulation, metabolic pathways, and GABAergic inhibition within the amygdalaJessica ZhouUniversity of California San Diego
13In-person1:15 pmAttribution of incentive salience to reward cues is genetically associated with other addiction-related traits in outbred hetergeneous stock ratsChristopher KingUniversity at Buffalo
14In-person1:30 pmGenome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traitsApurva ChitreUniversity of California San Diego
15In-person1:45 pmIdentification of actionable target genes that regulate breast cancer progression by genetic linkage analysis in HER2/Neu Transgenic Diversity Outbred (DO) F1 miceJennifer JacobWayne State University
162:00 pmBREAK
17Virtual2:15 pmMultiple genome viewer (MGV): a new tool for visualization and comparison of multiple annotated genomesMichelle PerryThe Jackson Laboratory
18Virtual2:30 pmInitial effort in generating a rat pangenomeFlavia VillaniUniversity of Tennessee Health Science Center
19Virtual2:45 pmWhich mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred populationGregory KeeleThe Jackson Laboratory
20In-person3:00 pmHybrid genotyping pipeline on Lc-WGS and ddGBS sequences for heterogeneous stock ratsDenghui ChenUniversity of California San Diego
21In-person3:15 pmThe Rat Genome Database resources for de novo rat strain assemblies Jennifer SmithMedical College of Wisconsin 
223:30 pmBREAK
23Virtual3:45 pmGenetic analysis of multi-omic data identifies drivers of protein phosphorylationGary ChurchillThe Jackson Laboratory
24Virtual4:00 pmIncreasing power in inbred strain association mapping by recognizing variance heterogeneityWilliam ValdarUniversity of North Carolina at Chapel Hill
25Virtual4:15 pmThe regulatory landscape of multiple brain regions in outbred heterogeneous stock ratsDan MunroUniversity of California San Diego & Scripps Research
26In-person4:30 pmA novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeate expansions in miceCynthia Wu University of California San Diego
27In-person4:45 pmPolygenic transcriptome risk scores can translate genetic results between speciesAbraham PalmerUniversity of California San Diego
29Genetic Loci Associated with Skeletal Response to PTH TherapyDouglas Adams University of Colorado Anschutz Medical Campus
30PhenoMiner: RGD's quantitative phenotype data repository has data update and data mining tool improvementsMary KaldunskiMedical College of Wisconsin
31PhenoGen: HRDP Transcriptome Data and APISpencer MahaffeyUniversity of Colorado Anschutz Medical Campus
32Characterization of polymorphic short tandem repeats and their association with phenotypes in HS ratsRyan EveloffUniversity of California San Diego
33Improving de novo genome assemblies of the HXB/BXH family of inbred strains using Hi-C dataPanjun KimUniversity of Tennessee Health Science Center
34Completion of genomic rat variants analysis of the Hybrid Rat Diversity PanelMonika TutajMedical College of Wisconsin
356:00 pmOptional Group Dinner
Index Type Time (MDT) Title Speaker Affiliation
01 8:00 am Registration open/Light Breakfast
02 9:00 am Developing a Model of Cannabis Psychopharmacology and Harm Reduction: Empirical Investigations Using Legal Market Products L. Cinnamon Bidwell University of Colorado Boulder
0310:00 amBREAK
04Virtual10:15 amDissecting the mechanisms of indirect genetic effects in outbred mouse populationHelene TonneleCentre for Genomic Regulation of Barcelona
05Virtual10:30 amAlternative splicing of osteopontin in CRISPR/Cas9 knock out ratsCara TrivettUniversity of Glasgow
06Virtual10:45 amIncorporating strain-specific variance into genome-wide inbred strain mapping for zero-inflated phenotypesTeresa McGeeUniversity of North Carolina Chapel Hill
07In-person11:00 amScalable in vitro model using scRNA-seq to generate cell-type specific transcriptome profiles of osteogenic cellsLuke DillardUniversity of Virginia
08In-person11:15 amAdjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organismsJack PatteeUniversity of Colorado Anschutz Medical Campus
0911:30 amLunch - box lunches provided
10Virtual12:30 pmGenetic analysis of CNS autoimmunity using the diversity of the Collaborative Cross reveals unique phenotypes and mechanismsEmily HoltUniversity of Vermont
11Virtual12:45 pmOPEN
12Virtual1:00 pmGenetic regulation of heart mitochondrial proteome influencing heart functionKarthickeyan Chella KrishnanUniversity of Cincinnati
13Virtual1:15 pmGene-by-treatment QTL mapping to dissect genetic susceptibility to severe coronavirus diseaseEllen RisembergUniversity of North Carolina Chapel Hill
141:30 pmBREAK
15Virtual1:45 pmNetwork-based analysis predicts interacting genetic modifiers from a mapping study of multiple absence epilepsy mouse modelsMontana LaraUniversity of Vermont
16Virtual2:00 pmGRK5 is required for adipogenesis through activation of ERK pathwayMary SeramurWake Forest University
17Virtual2:15 pmAdcy3 knock-out rats show increased adiposity without changes in behavioral phenotypesMackenzie RobertsWake Forest University
18In-person2:30 pmClassifying the discrete epigenetic environment involved in drug-seeking behavior Carl Litif University of Wyoming 
192:45 pmBREAK
203:00 pmA genetic basis for oxidative stress response variationCallan O'ConnorThe Jackson Laboratory
213:15 pmGenetic background in the rat impacts metabolic outcomes of post-wean BPF exposure Valerie Wagner Medical College of Wisconsin, USA 
223:30 pmStructural equation modeling uncovers candidate genes for cocaine's conditioned effects in heterogeneous stock ratsJoel Leal-GutierrezUniversity of California San Diego
233:45 pmGenome-wide association studies of human and rat body mass index converge on a conserved molecular networkBrittany LegerUniversity of California San Diego
244:00 pmGenome-wide association study finds multiple loci associated with intraocular pressure in HS ratsOksana PolesskayaUniversity of California San Diego
254:15 pmClosing Remarks